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Found 5 Enz. Inhib. hit(s) with Target = 'Histamine H3 receptor' and Ligand = 'BDBM50269055'
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269055((4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isop...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-RAMH from human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269055((4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isop...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269055((4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isop...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269055((4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isop...)
Affinity DataEC50:  2nMAssay Description:Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269055((4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isop...)
Affinity DataEC50:  5nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed