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Found 5 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 11' and Ligand = 'BDBM417049'
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  746nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  5.72E+3nMAssay Description:Inhibition of recombinant human HDAC11 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  5.72E+3nMAssay Description:Inhibition of full length human recombinant HDAC11 using RHKKAc-AMC fluorogenic peptide as substrate incubated for 2 hrs by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  5.72E+3nMAssay Description:Inhibition of full-length recombinant human HDAC11 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board Of Trustees Of The University Of Illinois

US Patent
LigandPNGBDBM417049(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC11 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed