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Found 5 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM24624'
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:The HDAC enzyme in vitro assay was based on a homogeneous fluorescence release assay. Purified recombinant HDAC enzymes were incubated with compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NH2-terminal His-tagged HDAC8 expressed in sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of His-flagged recombinant HDAC8 (unknown origin) expressed in Escherichia coli BL21 pre-incubated for 15 mins before substrate addition b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed