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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor (HIF-PH2)' and Ligand = 'BDBM123028'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123028
PNG
(US8742138, 13)
Show SMILES COc1ccc(cc1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO7/c1-26-12-5-2-10(3-6-12)11-4-7-13-14(8-11)16(19(25)27-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
PDB
MMDB

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US Patent
n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair