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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor (HIF-PH2)' and Ligand = 'BDBM123041'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123041
PNG
(US8742138, 26)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C18H10F3NO6/c19-10-4-7(5-11(20)15(10)21)8-2-1-3-9-13(8)14(18(27)28-17(9)26)16(25)22-6-12(23)24/h1-5,26H,6H2,(H,22,25)(H,23,24)
PDB
MMDB

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US Patent
n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair