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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'IDH2(R140Q)' and Ligand = 'BDBM339591'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH2(R140Q)


(Homo sapiens (Human))
BDBM339591
PNG
(US10202339, Compound 35)
Show SMILES Fc1ccccc1NC(=O)Nc1cc(ccc1-c1ccccc1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C22H20FN3O3S/c23-19-8-4-5-9-20(19)24-22(27)25-21-14-17(30(28,29)26-16-10-11-16)12-13-18(21)15-6-2-1-3-7-15/h1-9,12-14,16,26H,10-11H2,(H2,24,25,27)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...


US Patent US10202339 (2019)

More data for this
Ligand-Target Pair