BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'IDH2(R140Q)' and Ligand = 'BDBM339601'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH2(R140Q)


(Homo sapiens (Human))
BDBM339601
PNG
(US10202339, Compound 45)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccccc2)S(=O)(=O)NC2COC2)c1
Show InChI InChI=1S/C23H20F3N3O4S/c24-23(25,26)16-7-4-8-17(11-16)27-22(30)28-21-12-19(34(31,32)29-18-13-33-14-18)9-10-20(21)15-5-2-1-3-6-15/h1-12,18,29H,13-14H2,(H2,27,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...


US Patent US10202339 (2019)

More data for this
Ligand-Target Pair