BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'IDH2(R140Q)' and Ligand = 'BDBM339624'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH2(R140Q)


(Homo sapiens (Human))
BDBM339624
PNG
(US10202339, Compound 68)
Show SMILES Fc1ccc(NC(=O)Nc2cc(ccc2-c2ccccc2)S(=O)(=O)NCC(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H16F5N3O3S/c22-14-6-9-18(17(23)10-14)28-20(30)29-19-11-15(33(31,32)27-12-21(24,25)26)7-8-16(19)13-4-2-1-3-5-13/h1-11,27H,12H2,(H2,28,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...


US Patent US10202339 (2019)

More data for this
Ligand-Target Pair