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Found 8 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM310197'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50:  210nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >1.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50: >5.00E+4nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM310197(US10945994, Compound 2a | US9603836, Compound 2a |...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed