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Found 3 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM312072'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(3-(6-chloro-5-fluoro-1H- indol-3-yl)pyrrolidine- 2...)
Affinity DataIC50:  490nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(3-(6-chloro-5-fluoro-1H- indol-3-yl)pyrrolidine- 2...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(3-(6-chloro-5-fluoro-1H- indol-3-yl)pyrrolidine- 2...)
Affinity DataIC50:  490nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent