BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM203290'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM203290
PNG
(US10227340, Example 31 | US9242975, 31)
Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(cs1)C(=O)N1CCN(CC1)c1ccc(F)cc1F
Show InChI InChI=1S/C29H27F2N7OS2/c1-17(2)34-23-13-27(35-19-4-5-22-26(12-19)41-16-33-22)32-14-20(23)28-36-24(15-40-28)29(39)38-9-7-37(8-10-38)25-6-3-18(30)11-21(25)31/h3-6,11-17H,7-10H2,1-2H3,(H2,32,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 764n/an/an/an/a7.225



Bristol-Myers Squibb Company

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substrates...


US Patent US9242975 (2016)


BindingDB Entry DOI: 10.7270/Q2MC8XVD
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM203290
PNG
(US10227340, Example 31 | US9242975, 31)
Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(cs1)C(=O)N1CCN(CC1)c1ccc(F)cc1F
Show InChI InChI=1S/C29H27F2N7OS2/c1-17(2)34-23-13-27(35-19-4-5-22-26(12-19)41-16-33-22)32-14-20(23)28-36-24(15-40-28)29(39)38-9-7-37(8-10-38)25-6-3-18(30)11-21(25)31/h3-6,11-17H,7-10H2,1-2H3,(H2,32,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 764n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...


US Patent US10227340 (2019)

More data for this
Ligand-Target Pair