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Found 4 Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP] cytoplasmic' and Ligand = 'BDBM445370'
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445370((S)-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H...)
Affinity DataIC50:  10nMAssay Description:Inhibition of IDH1 in human HT1080 cells assessed as decrease in 2-HG levels after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445370((S)-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H...)
Affinity DataIC50: <100nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) using alpha-KG as substrate after 60 mins by resazurin based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445370((S)-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM445370((S)-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In DepthDetails US Patent