BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'JAK2 (831-1132)' and Ligand = 'BDBM264204'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK2 (831-1132)


(Homo sapiens (Human))
BDBM264204
PNG
((2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-py...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
Show InChI InChI=1S/C25H30FN9O2/c1-15(35-10-8-33(2)9-11-35)23(36)29-19-7-5-6-16-17(12-27-22(16)19)21-18(26)13-28-25(31-21)30-20-14-34(3)32-24(20)37-4/h5-7,12-15,27H,8-11H2,1-4H3,(H,29,36)(H,28,30,31)/t15-/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.62E+3n/an/an/an/a7.3n/a



ASTRAZENECA AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)

More data for this
Ligand-Target Pair