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Found 1 hit Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50001715'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50001715
PNG
(CHEMBL407685 | Norbinaltorphimine3,3'-diether)
Show SMILES COC(=O)C(=C)COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)c1[nH]c2[C@@H]4Oc6c7c(C[C@H]8N(CC9CC9)CC[C@@]47[C@@]8(O)Cc2c1C[C@@]35O)ccc6OCC(=C)C(=O)OC
Show InChI InChI=1S/C50H55N3O10/c1-25(45(54)58-3)23-60-33-11-9-29-17-35-49(56)19-31-32-20-50(57)36-18-30-10-12-34(61-24-26(2)46(55)59-4)42-38(30)48(50,14-16-53(36)22-28-7-8-28)44(63-42)40(32)51-39(31)43-47(49,37(29)41(33)62-43)13-15-52(35)21-27-5-6-27/h9-12,27-28,35-36,43-44,51,56-57H,1-2,5-8,13-24H2,3-4H3/t35-,36-,43+,44+,47+,48+,49-,50-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane


J Med Chem 35: 4589-94 (1993)


Article DOI: 10.1021/jm00102a012
BindingDB Entry DOI: 10.7270/Q27S7PCK
More data for this
Ligand-Target Pair