Found 59 Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50159165' 
Affinity DataKi: 0.75nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Displacement of [3H]U69,593 from rat cloned KORMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]diprenorphine binding from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of [125I]- IOXY binding to human Opioid receptor kappa1More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [125]OXY from kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]diprenorphine from human KOPR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]diprenorphine from human KOPR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]-U-69,593 binding to rat opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Case Western Reserve University
Curated by PDSP Ki Database
Case Western Reserve University
Curated by PDSP Ki Database
Affinity DataKi: 6.20nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nM ΔG°: -45.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 17.5nMAssay Description:Displacement of [3H]diprenorphine from rat kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]U69593 from C57BL6/J mouse brain KOPMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at kappa opioid receptor in human HEK293 cells assessed as stimulation of Galphai signaling by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0150nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin) assessed as increase in venus-tagged N-terminal beta-arrestin-2 recruitment by BRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin) expressed in HEK cells co-expressing luciferase based cAMP biosensor assessed as increase ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at human kappa opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at human KOR expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by lumi...More data for this Ligand-Target Pair
Affinity DataEC50: 104nMAssay Description:Agonist activity at C57BL6/J mouse brain KOP by calcium mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0420nMAssay Description:Agonist activity at human kappa-type opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30...More data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at human kappa-type opioid receptor expressed in CHO-K1 cells assessed as forskolin-induced cAMP accumulation after 30 mins in prese...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintil...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 45nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human KOPR expressed in U2OS cells assessed as beta-arrestin2 recruitment after 90 mins by DiscoveRx PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.90nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 7.5nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as increase of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as enhancenment of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 6.90nMAssay Description:Agonist activity at C57BL6/J mouse brain KOPMore data for this Ligand-Target Pair
Affinity DataEC50: 1.24nMAssay Description:Agonist activity at human kappa opioid receptor assessed as inhibition of Galpha16-induced calcium fluxMore data for this Ligand-Target Pair
Affinity DataEC50: 2.82nMAssay Description:Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Binding potency at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.810nMAssay Description:Agonist activity at human kappa opioid receptor-Galpha16 fusion protein expressed in CHO cells by calcium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 45nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Stimulation of [35S]-GTP-gammaS, binding to Opioid receptor kappa1 expressed in CHO cellsMore data for this Ligand-Target Pair
