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Found 1 hit Enz. Inhib. hit(s) with Target = 'Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial' and Ligand = 'BDBM273025'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM273025
PNG
((R)-2-[5-(2,4-difluorophenyl)-7-oxo-6,7-dihydro[1,...)
Show SMILES Fc1ccc(c(F)c1)-c1nc2sc(nc2c(=O)[nH]1)[C@H]1CCCN1C(=O)Oc1ccccc1
Show InChI InChI=1S/C22H16F2N4O3S/c23-12-8-9-14(15(24)11-12)18-26-19(29)17-21(27-18)32-20(25-17)16-7-4-10-28(16)22(30)31-13-5-2-1-3-6-13/h1-3,5-6,8-9,11,16H,4,7,10H2,(H,26,27,29)/t16-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a8.0n/a



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...


US Patent US10065972 (2018)

More data for this
Ligand-Target Pair