BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Leucyl-cystinyl aminopeptidase' and Ligand = 'BDBM271210'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271210
PNG
(US10059720, Example 25)
Show SMILES CCCCCCn1ccc2cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc12
Show InChI InChI=1S/C21H33N3O3/c1-4-5-6-7-9-24-10-8-16-14-23-17(12-18(16)24)13-21(27,20(25)26)19(22)11-15(2)3/h8,10,12,14-15,19,27H,4-7,9,11,13,22H2,1-3H3,(H,25,26)/t19-,21+/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271210
PNG
(US10059720, Example 25)
Show SMILES CCCCCCn1ccc2cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc12
Show InChI InChI=1S/C21H33N3O3/c1-4-5-6-7-9-24-10-8-16-14-23-17(12-18(16)24)13-21(27,20(25)26)19(22)11-15(2)3/h8,10,12,14-15,19,27H,4-7,9,11,13,22H2,1-3H3,(H,25,26)/t19-,21+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)

More data for this
Ligand-Target Pair