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Found 3 Enz. Inhib. hit(s) with Target = 'Leukotriene C4 synthase' and Ligand = 'BDBM223227'
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223227(2-(5-((4-Chlorobenzyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50:  34nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223227(2-(5-((4-Chlorobenzyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50:  86nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223227(2-(5-((4-Chlorobenzyl)(cyclopropylmethyl)amino)-3-...)
Affinity DataIC50:  86nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent