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Found 1 hit Enz. Inhib. hit(s) with Target = 'Low affinity sodium-glucose cotransporter' and Ligand = 'BDBM50351435'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low affinity sodium-glucose cotransporter


(Homo sapiens (Human))
BDBM50351435
PNG
(CHEMBL1819489)
Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C2CC2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H28O5/c24-13-18-12-20(22(26)23(27)21(18)25)28-19-4-2-1-3-17(19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,16,18,20-27H,9-13H2/t18-,20-,21-,22+,23+/m1/s1
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Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins


Bioorg Med Chem 19: 5334-41 (2011)


Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R
More data for this
Ligand-Target Pair