BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM194700'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194700
PNG
(US10174030, Example 86 | US9670210, Example 86 1-{...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3F)C#N)CC2)CCC1
Show InChI InChI=1S/C29H34FN3O3/c30-24-15-21(17-31)7-8-26(24)36-20-28(18-32-25-16-23(25)22-5-2-1-3-6-22)11-13-33(14-12-28)19-29(27(34)35)9-4-10-29/h1-3,5-8,15,23,25,32H,4,9-14,16,18-20H2,(H,34,35)/t23?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US10174030 (2019)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM194700
PNG
(US10174030, Example 86 | US9670210, Example 86 1-{...)
Show SMILES OC(=O)C1(CN2CCC(CN[C@@H]3CC3c3ccccc3)(COc3ccc(cc3F)C#N)CC2)CCC1
Show InChI InChI=1S/C29H34FN3O3/c30-24-15-21(17-31)7-8-26(24)36-20-28(18-32-25-16-23(25)22-5-2-1-3-6-22)11-13-33(14-12-28)19-29(27(34)35)9-4-10-29/h1-3,5-8,15,23,25,32H,4,9-14,16,18-20H2,(H,34,35)/t23?,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/a7.5n/a



Incyte Corporation

US Patent


Assay Description
LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9670210 (2017)


BindingDB Entry DOI: 10.7270/Q2H1306F
More data for this
Ligand-Target Pair