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Found 1 hit Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM301039'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301039
PNG
(4-[5-(4-methylphenyl)-2-[(piperidin-4- ylmethyl)am...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2CCNCC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5/c1-17-2-6-20(7-3-17)22-16-28-24(27-15-19-10-12-26-13-11-19)29-23(22)21-8-4-18(14-25)5-9-21/h2-9,16,19,26H,10-13,15H2,1H3,(H,27,28,29)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair