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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM301113'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301113
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(2- methylpyrazo...)
Show SMILES Cn1nccc1C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN7/c1-29-19(6-9-27-29)5-4-17-14-26-22(30-10-7-18(25)8-11-30)28-21(17)15-2-3-16(13-24)20(23)12-15/h2-3,6,9,12,14,18H,7-8,10-11,25H2,1H3
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair