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Found 3 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM18428'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataKi:  21nM ΔG°:  -43.2kJ/mole IC50:  31nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataIC50:  30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed