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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1/2' and Ligand = 'BDBM375581'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM375581
PNG
(4-(6-(3-chloro-4-(4-methylpiperazine-1-carbonyl)ph...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1Cl)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Show InChI InChI=1S/C26H22ClN5O/c1-30-10-12-31(13-11-30)26(33)22-8-6-20(14-23(22)27)21-7-9-25-29-16-24(32(25)17-21)19-4-2-18(15-28)3-5-19/h2-9,14,16-17H,10-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Agency for Science, Technology and Research

US Patent


Assay Description
MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...


US Patent US9908886 (2018)

More data for this
Ligand-Target Pair