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Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)' and Ligand = 'BDBM176754'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176754
PNG
(US9675612, 5 N-(6-Methoxy-1H-indazol-5-yl)-2-(meth...)
Show SMILES COCc1nc2c(Nc3cc4cn[nH]c4cc3OC)ncnc2s1
Show InChI InChI=1S/C15H14N6O2S/c1-22-6-12-20-13-14(16-7-17-15(13)24-12)19-10-3-8-5-18-21-9(8)4-11(10)23-2/h3-5,7H,6H2,1-2H3,(H,18,21)(H,16,17,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair