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Found 2 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)' and Ligand = 'BDBM337241'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337241
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C19H12N6O4/c26-17-8-11(21-19(28)23-17)18(27)22-15-5-6-16-20-9-12(25(16)24-15)14-7-10-3-1-2-4-13(10)29-14/h1-9H,(H,22,24,27)(H2,21,23,26,28)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337241
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES O=C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C19H12N6O4/c26-17-8-11(21-19(28)23-17)18(27)22-15-5-6-16-20-9-12(25(16)24-15)14-7-10-3-1-2-4-13(10)29-14/h1-9H,(H,22,24,27)(H2,21,23,26,28)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair