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Found 2 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)' and Ligand = 'BDBM337248'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337248
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337248
PNG
(N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...)
Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 4n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)


Article DOI: 10.1016/j.bmcl.2004.10.092
More data for this
Ligand-Target Pair