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Found 2 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)' and Ligand = 'BDBM337251'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337251
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cn1cc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)cn1
Show InChI InChI=1S/C21H18N6O2/c1-26-13-14(11-23-26)6-9-21(28)24-19-7-8-20-22-12-16(27(20)25-19)18-10-15-4-2-3-5-17(15)29-18/h2-5,7-8,10-13H,6,9H2,1H3,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337251
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cn1cc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)cn1
Show InChI InChI=1S/C21H18N6O2/c1-26-13-14(11-23-26)6-9-21(28)24-19-7-8-20-22-12-16(27(20)25-19)18-10-15-4-2-3-5-17(15)29-18/h2-5,7-8,10-13H,6,9H2,1H3,(H,24,25,28)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair