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Found 2 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)' and Ligand = 'BDBM337262'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337262
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cc1cccc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)c1
Show InChI InChI=1S/C24H20N4O2/c1-16-5-4-6-17(13-16)9-12-24(29)26-22-10-11-23-25-15-19(28(23)27-22)21-14-18-7-2-3-8-20(18)30-21/h2-8,10-11,13-15H,9,12H2,1H3,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 67n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM337262
PNG
(N-[3-(1-benzofuran-2- yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES Cc1cccc(CCC(=O)Nc2ccc3ncc(-c4cc5ccccc5o4)n3n2)c1
Show InChI InChI=1S/C24H20N4O2/c1-16-5-4-6-17(13-16)9-12-24(29)26-22-10-11-23-25-15-19(28(23)27-22)21-14-18-7-2-3-8-20(18)30-21/h2-8,10-11,13-15H,9,12H2,1H3,(H,26,27,29)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 67n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9745304 (2017)

More data for this
Ligand-Target Pair