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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM135706'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135706
PNG
(US10179804, Example 91 | US8846601, 91 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-31(14-7-20-55-47(50)51)40(68)60-33-17-18-39(67)54-19-9-16-34(46(74)75)61-44(72)36(23-28-25-57-30-13-6-5-12-29(28)30)63-41(69)32(15-8-21-56-48(52)53)59-43(71)35(22-27-10-3-2-4-11-27)62-45(73)37(24-38(49)66)64-42(33)70/h2-6,10-13,25,31-37,57H,7-9,14-24H2,1H3,(H2,49,66)(H,54,67)(H,58,65)(H,59,71)(H,60,68)(H,61,72)(H,62,73)(H,63,69)(H,64,70)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
167n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135706
PNG
(US10179804, Example 91 | US8846601, 91 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-31(14-7-20-55-47(50)51)40(68)60-33-17-18-39(67)54-19-9-16-34(46(74)75)61-44(72)36(23-28-25-57-30-13-6-5-12-29(28)30)63-41(69)32(15-8-21-56-48(52)53)59-43(71)35(22-27-10-3-2-4-11-27)62-45(73)37(24-38(49)66)64-42(33)70/h2-6,10-13,25,31-37,57H,7-9,14-24H2,1H3,(H2,49,66)(H,54,67)(H,58,65)(H,59,71)(H,60,68)(H,61,72)(H,62,73)(H,63,69)(H,64,70)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
167n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135706
PNG
(US10179804, Example 91 | US8846601, 91 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-31(14-7-20-55-47(50)51)40(68)60-33-17-18-39(67)54-19-9-16-34(46(74)75)61-44(72)36(23-28-25-57-30-13-6-5-12-29(28)30)63-41(69)32(15-8-21-56-48(52)53)59-43(71)35(22-27-10-3-2-4-11-27)62-45(73)37(24-38(49)66)64-42(33)70/h2-6,10-13,25,31-37,57H,7-9,14-24H2,1H3,(H2,49,66)(H,54,67)(H,58,65)(H,59,71)(H,60,68)(H,61,72)(H,62,73)(H,63,69)(H,64,70)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
167 -40.2n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair