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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM135753'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US10179804, Example 138 | US8846601, 138 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
0.800n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US10179804, Example 138 | US8846601, 138 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
0.800n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US10179804, Example 138 | US8846601, 138 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
0.800 -54.0n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair