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Found 2 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50345552'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345552(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-chlorobenzon...)
Affinity DataKi:  0.127nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345552(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-chlorobenzon...)
Affinity DataIC50:  1.61nMAssay Description:Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed