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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM243247'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM243247
PNG
((s)-n-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-((2...)
Show SMILES Cc1cc(Nc2ncc3c(CN(C(=O)N[C@H](CO)c4ccccc4)C3(C)C)n2)ccn1
Show InChI InChI=1S/C23H26N6O2/c1-15-11-17(9-10-24-15)26-21-25-12-18-19(27-21)13-29(23(18,2)3)22(31)28-20(14-30)16-7-5-4-6-8-16/h4-12,20,30H,13-14H2,1-3H3,(H,28,31)(H,24,25,26,27)/t20-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...


US Patent US9546173 (2017)

More data for this
Ligand-Target Pair