Found 13 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM50094465'
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKi: 0.0400nMAssay Description:Binding affinity to ERK2 (unknown origin) measured after 20 mins in presence of [gamma33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <50nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: <50nMAssay Description:Activated ERK1 and ERK2 activity was determined in a Mobility Shift Assay (MSA) format as follows: Compound and kinase solution were prepared with as...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKd: 0.316nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataKd: 10nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair