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Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 12 (p38MAPgamma)' and Ligand = 'BDBM334355'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 12 (p38MAPgamma)


(Homo sapiens (Human))
BDBM334355
PNG
(1-(4-((2-((3-Methoxy-5-(2-(2-(2-methoxyethoxyl)eth...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(F)(F)C(F)(F)F)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C41H40F5N7O7/c1-26-8-10-28(11-9-26)53-36(25-35(52-53)40(42,43)41(44,45)46)50-39(54)49-33-12-13-34(32-7-5-4-6-31(32)33)60-37-14-15-47-38(51-37)48-27-22-29(56-3)24-30(23-27)59-21-20-58-19-18-57-17-16-55-2/h4-15,22-25H,16-21H2,1-3H3,(H,47,48,51)(H2,49,50,54)
PDB
MMDB

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Article
US Patent
n/an/a 433n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9732063 (2017)


Article DOI: 10.1021/jm060978s
More data for this
Ligand-Target Pair