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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 12 (p38MAPgamma)' and Ligand = 'BDBM334386'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 12 (p38MAPgamma)


(Homo sapiens (Human))
BDBM334386
PNG
(1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)S(=O)(=O)C3CC3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C39H39N7O6S/c1-39(2,3)34-23-35(46(45-34)25-10-12-26(50-4)13-11-25)43-38(47)42-32-16-17-33(31-9-7-6-8-30(31)32)52-36-18-19-40-37(44-36)41-24-20-27(51-5)22-29(21-24)53(48,49)28-14-15-28/h6-13,16-23,28H,14-15H2,1-5H3,(H,40,41,44)(H2,42,43,47)
PDB
MMDB

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US Patent
n/an/a 300n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair