BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM298384'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM298384
PNG
(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-cyano-4-(2-morph...)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(OCCN5CCOCC5)c(c4)C#N)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C41H45N7O7S/c1-41(2,3)28-23-34(39(52-4)35(24-28)47-56(5,50)51)46-40(49)45-33-11-13-37(32-9-7-6-8-31(32)33)55-30-14-15-43-38(25-30)44-29-10-12-36(27(22-29)26-42)54-21-18-48-16-19-53-20-17-48/h6-15,22-25,47H,16-21H2,1-5H3,(H,43,44)(H2,45,46,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 197n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...


US Patent US9751837 (2017)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM298384
PNG
(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-cyano-4-(2-morph...)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(OCCN5CCOCC5)c(c4)C#N)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C41H45N7O7S/c1-41(2,3)28-23-34(39(52-4)35(24-28)47-56(5,50)51)46-40(49)45-33-11-13-37(32-9-7-6-8-31(32)33)55-30-14-15-43-38(25-30)44-29-10-12-36(27(22-29)26-42)54-21-18-48-16-19-53-20-17-48/h6-15,22-25,47H,16-21H2,1-5H3,(H,43,44)(H2,45,46,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 197n/an/an/an/an/an/a



Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level...


US Patent US10125100 (2018)

More data for this
Ligand-Target Pair