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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM21899'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM21899
PNG
(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Show SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C20H13BrClFN6/c21-16-4-13(26-9-14-8-25-10-28-14)3-15-19(11(6-24)7-27-20(15)16)29-12-1-2-18(23)17(22)5-12/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29)
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Article
PubMed
n/an/a 10n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...


J Med Chem 50: 4728-45 (2007)

More data for this
Ligand-Target Pair