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Found 1 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8' and Ligand = 'BDBM29921'
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29921(substituted 6-aminoquinoline-3-carbonitrile, 32)
Affinity DataIC50:  5.30nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed