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Found 4 hits Enz. Inhib. hit(s) with Target = 'Monoacylglycerol acyltransferase type 2 (h-MGAT2)' and Ligand = 'BDBM201317'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM201317
PNG
(US9187424, 81 | US9187424, 91)
Show SMILES COc1ccc(C2=C(C#N)C(=O)NC(C2)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1/C24H19F7N2O3/c1-35-16-7-8-17(20(25)11-16)18-12-22(24(29,30)31,33-21(34)19(18)13-32)14-3-5-15(6-4-14)36-10-2-9-23(26,27)28/h3-8,11H,2,9-10,12H2,1H3,(H,33,34)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM201317
PNG
(US9187424, 81 | US9187424, 91)
Show SMILES COc1ccc(C2=C(C#N)C(=O)NC(C2)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1/C24H19F7N2O3/c1-35-16-7-8-17(20(25)11-16)18-12-22(24(29,30)31,33-21(34)19(18)13-32)14-3-5-15(6-4-14)36-10-2-9-23(26,27)28/h3-8,11H,2,9-10,12H2,1H3,(H,33,34)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff...


US Patent US9187424 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM201317
PNG
(US9187424, 81 | US9187424, 91)
Show SMILES COc1ccc(C2=C(C#N)C(=O)NC(C2)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1/C24H19F7N2O3/c1-35-16-7-8-17(20(25)11-16)18-12-22(24(29,30)31,33-21(34)19(18)13-32)14-3-5-15(6-4-14)36-10-2-9-23(26,27)28/h3-8,11H,2,9-10,12H2,1H3,(H,33,34)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 55n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)

More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM201317
PNG
(US9187424, 81 | US9187424, 91)
Show SMILES COc1ccc(C2=C(C#N)C(=O)NC(C2)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c(F)c1
Show InChI InChI=1/C24H19F7N2O3/c1-35-16-7-8-17(20(25)11-16)18-12-22(24(29,30)31,33-21(34)19(18)13-32)14-3-5-15(6-4-14)36-10-2-9-23(26,27)28/h3-8,11H,2,9-10,12H2,1H3,(H,33,34)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 916n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy...


US Patent US9187424 (2015)

More data for this
Ligand-Target Pair