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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Monoacylglycerol acyltransferase type 2 (h-MGAT2)' and Ligand = 'BDBM235256'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235256
PNG
(US9365558, 79)
Show SMILES FC(F)(F)CCCCCOc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C29H32F6N4O5S/c30-28(31,32)13-2-1-3-15-44-20-8-6-19(7-9-20)27(29(33,34)35)16-22(23-12-14-39(37-23)17-18-4-5-18)24(25(40)36-27)26(41)38-45(42,43)21-10-11-21/h6-9,12,14,18,21H,1-5,10-11,13,15-17H2,(H,36,40)(H,38,41)/t27-/s2
UniProtKB/SwissProt

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US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


US Patent US9365558 (2016)

More data for this
Ligand-Target Pair