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Found 14 Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M2' and Ligand = 'BDBM50074569'
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  407nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  646nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  851nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataKi:  1.41E+3nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataIC50:  479nMAssay Description:Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataEC50:  1.00E+3nMAssay Description:Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(GUINEA PIG)
University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataEC50:  1.41E+3nMAssay Description:Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(GUINEA PIG)
University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataEC50:  1.35E+3nMAssay Description:Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(GUINEA PIG)
University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataEC50:  1.44E+3nMAssay Description:Allosteric potency against the dissociation of radioligand [3H]-N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(GUINEA PIG)
University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50074569((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...)
Affinity DataEC50:  1.44E+3nMAssay Description:Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed