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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase (NAMPT)' and Ligand = 'BDBM180264'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180264
PNG
(US9676721, 95 2-cyano-3-(pyridin-4-yl)-1-{[4-({4-[...)
Show SMILES O=C(N1CCCC1)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C25H24N6O3S/c26-18-29-25(30-21-11-13-27-14-12-21)28-17-19-3-7-22(8-4-19)35(33,34)23-9-5-20(6-10-23)24(32)31-15-1-2-16-31/h3-14H,1-2,15-17H2,(H2,27,28,29,30)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 4.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair