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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase (NAMPT)' and Ligand = 'BDBM180928'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180928
PNG
(US9676721, 97 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cnc2ccccc2c1
Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-9-11-25-12-10-19)27-14-17-5-7-20(8-6-17)32(30,31)21-13-18-3-1-2-4-22(18)26-15-21/h1-13,15H,14H2,(H2,25,27,28,29)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair