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Found 2 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM285776'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285776((R)-3-(5-(4-(cyclobutylmethyl)-5-(2-(difluoromethy...)
Affinity DataIC50:  76nMT: 2°CAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285776((R)-3-(5-(4-(cyclobutylmethyl)-5-(2-(difluoromethy...)
Affinity DataKd:  1.30nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent