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Found 3 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7' and Ligand = 'BDBM446086'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50:  39.7nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50:  144nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Axxam

US Patent
LigandPNGBDBM446086(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(4...)
Affinity DataIC50:  144nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest™ Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest®). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent