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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'PRMT5/MEP50 Enzyme' and Ligand = 'BDBM343915'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343915
PNG
(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-(pyrro...)
Show SMILES OC(COc1cccc(c1)-c1ccc2ncn(C3CCNC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C29H32N4O2/c34-26(18-32-13-11-21-4-1-2-5-24(21)17-32)19-35-27-7-3-6-22(14-27)23-8-9-28-29(15-23)33(20-31-28)25-10-12-30-16-25/h1-9,14-15,20,25-26,30,34H,10-13,16-19H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair