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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'PRMT5/MEP50 Enzyme' and Ligand = 'BDBM343933'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343933
PNG
(US9777008, Compound 227)
Show SMILES Cn1ccc2ccc(cc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1
Show InChI InChI=1S/C26H28N4O/c1-29-12-9-20-6-7-21(14-25(20)29)22-8-11-27-26(15-22)28-16-24(31)18-30-13-10-19-4-2-3-5-23(19)17-30/h2-9,11-12,14-15,24,31H,10,13,16-18H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair