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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'PRMT5/MEP50 Enzyme' and Ligand = 'BDBM343946'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343946
PNG
(US9777008, Compound 240)
Show SMILES OC(CNc1cc(ccn1)-c1ccc2ncn(C3CCNC3)c2c1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C28H32N6O/c35-25(18-33-12-9-20-3-1-2-4-23(20)17-33)16-31-28-14-22(7-11-30-28)21-5-6-26-27(13-21)34(19-32-26)24-8-10-29-15-24/h1-7,11,13-14,19,24-25,29,35H,8-10,12,15-18H2,(H,30,31)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair