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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'PRMT5/MEP50 Enzyme' and Ligand = 'BDBM343959'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM343959
PNG
(US9777008, Compound 253)
Show SMILES OC(COc1cccc(c1)-c1ncc2ccn(C3CCNCC3)c2n1)CN1CCc2ccccc2C1
Show InChI InChI=1S/C29H33N5O2/c35-26(19-33-14-10-21-4-1-2-5-24(21)18-33)20-36-27-7-3-6-22(16-27)28-31-17-23-11-15-34(29(23)32-28)25-8-12-30-13-9-25/h1-7,11,15-17,25-26,30,35H,8-10,12-14,18-20H2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US9777008 (2017)

More data for this
Ligand-Target Pair